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Target intelligence / Profile preview
Beta Klotho Coreceptor (KLB)
- Target
- KLB
- Molecular classification
- Type I transmembrane protein, Coreceptor
01
Overview
Beta klotho (KLB) is a type I transmembrane protein that functions as an essential coreceptor in the signaling pathways of certain endocrine fibroblast growth factors, specifically FGF19 and FGF21. It is primarily expressed in the liver, adipose tissue, and pancreas, and plays a key role in metabolic regulation. KLB is indispensable for mediating specific endocrine actions of select fibroblast growth factors by acting as their high-affinity coreceptor alongside canonical tyrosine kinase receptors. Its modulation offers therapeutic potential but also presents challenges due to interspecies differences affecting translational outcomes from animal models to human patients.
02
Mechanism of action
Forms complex with FGFRs upon FGF19/FGF21 binding, activating downstream signaling pathways.
03
Biological functions
Coreceptor for FGF19 and FGF21 signalingBile acid synthesis regulationGlucose metabolismLipid metabolismEnergy homeostasis
04
Disease associations
Type 2 diabetes mellitus (T2D)Non-alcoholic fatty liver disease (NAFLD)Cardiovascular disease
05
Safety considerations
Species-specific differences in tissue expression patterns between rodents and humans may affect translational outcomes.Potential for variable efficacy across species.
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