Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Beta-lactamase
- Molecular classification
- Enzyme, Hydrolase, Serine beta-lactamase, Metallo-beta-lactamase
01
Overview
Beta-lactamase is an enzyme produced by bacteria that confers resistance to beta-lactam antibiotics by hydrolyzing the beta-lactam ring. They are classified into four classes (A, B, C, D) based on their structure and mechanism of action. Beta-lactamases are a major cause of antibiotic resistance, especially among Gram-negative bacteria.
- Other names
- β-LactamaseBeta lactamaseEC 3.5.2.6TEM-type beta-lactamasesKPCsNDMIMPVIMAmpCOxacillinasesOXAsExtended-spectrum beta-lactamasesESBLs
02
Mechanism of action
Hydrolyzes the beta-lactam ring of beta-lactam antibiotics, inactivating their antibacterial properties. Serine beta-lactamases form an acyl-enzyme intermediate, while metallo-beta-lactamases utilize Zn²⁺ ions to activate water molecules for direct hydrolysis.
03
Biological functions
Hydrolyzes beta-lactam ring of beta-lactam antibioticsConfers antibiotic resistanceDrug inactivation
04
Disease associations
InfectionAntibiotic resistance
05
Safety considerations
Contributes to antibiotic resistanceLimits treatment options for bacterial infectionsEmergence of extended-spectrum beta-lactamases (ESBLs)
06
Interacting drugs
Penicillins
4 more in the full profile.
07
Biomarkers
Nitrocefin cleavage (detection of enzymatic activity)Presence of beta-lactamase genes (e.g., blaTEM, blaKPC, blaNDM)
Beyond the preview
Go deeper on Beta-lactamase.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Beta-lactamase.