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Target intelligence / Profile preview
Beta-lactamase Enzyme (N/A)
- Target
- N/A
- Molecular classification
- Enzyme, Hydrolase, Serine Beta-Lactamase, Metallo-Beta-Lactamase, Class A Beta-Lactamase, Class B Beta-Lactamase, Class C Beta-Lactamase, Class D Beta-Lactamase
01
Overview
Beta-lactamases are enzymes produced by bacteria that confer resistance to beta-lactam antibiotics by hydrolyzing the beta-lactam ring. They are classified into four main classes (A-D) based on their molecular structure and mechanism of action. Beta-lactamase production is a major mechanism of antibiotic resistance, leading to multi-drug resistant infections worldwide. Understanding the specific types of beta-lactamases present in pathogens is crucial for guiding therapy choices and infection control measures.
- Other names
- Beta-lactamasesβ-lactamaseβ-lactamasesTEMSHVCTX-MKPCNDMIMPVIMAmpCOXA-type
02
Mechanism of action
Hydrolysis of the beta-lactam ring of antibiotics, rendering them ineffective. Serine beta-lactamases form an acyl-enzyme intermediate that is subsequently hydrolyzed. Metallo-beta-lactamases utilize zinc ions to activate a water molecule that attacks the beta-lactam ring.
03
Biological functions
Hydrolyzes beta-lactam ring of antibioticsInactivates beta-lactam antibioticsConfers antibiotic resistance
04
Disease associations
InfectionAntibiotic resistanceMulti-drug resistant infections
05
Safety considerations
Spread of antibiotic resistance genesTreatment failure in infections caused by beta-lactamase producing bacteriaEmergence of new beta-lactamase variants with increased resistance
06
Interacting drugs
Penicillins
4 more in the full profile.
07
Biomarkers
Detection of specific beta-lactamase genes (e.g., blaKPC, blaNDM) in bacterial isolatesPhenotypic assays for beta-lactamase activity
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