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Beta-Lactamase Enzyme (Class A and C) (N/A)
- Target
- N/A
- Molecular classification
- Enzyme, Hydrolase, Serine-based Beta-Lactamase
01
Overview
Beta-lactamases are enzymes produced by bacteria that confer resistance to beta-lactam antibiotics by hydrolyzing the beta-lactam ring. Class A beta-lactamases hydrolyze penicillins and early-generation cephalosporins. Class C beta-lactamases (cephalosporinases) efficiently hydrolyze most cephalosporins. Production of these enzymes is a major mechanism of antibiotic resistance.
- Other names
- Class A Beta-LactamaseClass C Beta-LactamaseCephalosporinaseAmpC enzymes
02
Mechanism of action
Hydrolyzes beta-lactam ring via acylation and deacylation (Class A and C). Inhibition by beta-lactamase inhibitors (variable efficacy).
03
Biological functions
Hydrolyzing beta-lactam ring of beta-lactam antibioticsAntibiotic resistance
04
Disease associations
InfectionAntibiotic resistance
05
Safety considerations
Contributes to antibiotic resistanceLimits treatment options for bacterial infections
06
Interacting drugs
Penicillins
5 more in the full profile.
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