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Target intelligence / Profile preview
Beta-Lactamase Enzyme Ambler Class D (OXA)
- Target
- OXA
- Molecular classification
- Enzyme, Hydrolase, Beta-Lactamase, Ambler Class D Beta-Lactamase, Serine Beta-Lactamase
01
Overview
Beta-lactamase enzymes are bacterial enzymes that confer resistance to beta-lactam antibiotics by hydrolyzing the beta-lactam ring. Ambler class D beta-lactamases, also known as oxacillinases (OXA-type beta-lactamases), are serine-based enzymes. They exhibit significant genetic diversity, with variants showing different substrate specificities, including penicillins, cephalosporins, and carbapenems. Many Class D beta-lactamase genes are plasmid-borne, facilitating horizontal gene transfer and accelerating the spread of resistance traits.
- Other names
- OxacillinaseOXA-type beta-lactamase
02
Mechanism of action
Hydrolysis of beta-lactam ring in beta-lactam antibiotics via acyl-enzyme intermediate formation, rendering the antibiotic ineffective.
03
Biological functions
Antibiotic resistanceBeta-lactam hydrolysis
04
Disease associations
InfectionAntibiotic resistanceHospital-acquired infections
05
Safety considerations
Spread of antibiotic resistanceLimited treatment options for infections caused by bacteria producing Class D beta-lactamasesPotential for treatment failure with beta-lactam antibiotics
06
Interacting drugs
Penicillins
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