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Target intelligence / Profile preview
Beta-lactamase Ohio-1 (None)
- Target
- None
- Molecular classification
- Enzyme, Class A beta-lactamase, SHV-1 family beta-lactamase
01
Overview
Beta-lactamase Ohio-1 (OHIO-1) is a plasmid-mediated class A beta-lactamase enzyme, closely related to the SHV-1 family, that confers resistance to beta-lactam antibiotics by hydrolyzing their characteristic lactam ring. It is primarily effective against penicillins, with mutant variants exhibiting increased resistance to cephalosporins and reduced susceptibility to beta-lactamase inhibitors. The spread of OHIO-1 is a clinical concern due to its plasmid-mediated transmission and potential for developing inhibitor-resistant strains.
- Other names
- OHIO-1Beta-lactamase OHIO-1
02
Mechanism of action
Hydrolysis of the beta-lactam ring of beta-lactam antibiotics
03
Biological functions
Hydrolyzes beta-lactam antibioticsAntibiotic resistance
04
Disease associations
InfectionAntibiotic resistance
05
Safety considerations
Resistance to beta-lactam antibioticsSpread of resistance genes via plasmidsDevelopment of inhibitor-resistant mutants
06
Interacting drugs
Penicillins
5 more in the full profile.
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