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Beta-lactamase OXA-10 (None)

Target: None
Molecular classification: Enzyme, Class D β-Lactamase

Overview

Beta-lactamase OXA-10 is a class D β-lactamase enzyme found in Gram-negative bacteria. It hydrolyzes β-lactam antibiotics, conferring resistance. Its activity is primarily against penicillins and narrow-spectrum cephalosporins, with weaker activity against carbapenems unless combined with other resistance mechanisms. The gene encoding OXA-10 is often plasmid-borne and subject to mutation, leading to extended-spectrum variants.

Other names: OXA-10blaOXA-10

Mechanism of action

Hydrolyzes the β-lactam ring of antibiotics, rendering them ineffective.

Biological functions

Hydrolysis of beta-lactam antibioticsAntibiotic resistance

Disease associations

InfectionAntibiotic resistance

Safety considerations

Development of antibiotic resistanceLimited effectiveness of beta-lactam antibiotics

Interacting drugs

Penicillins

2 more in the full profile.

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