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Beta-lactamase SHV-1
- Molecular classification
- Enzyme, Beta-lactamase, Class A serine beta-lactamase
01
Overview
Beta-lactamase SHV-1 is a class A, group 2b serine beta-lactamase enzyme that confers resistance to beta-lactam antibiotics by hydrolyzing the beta-lactam ring. It is primarily associated with Klebsiella pneumoniae and has spread to other enterobacterial species via plasmids. While SHV-1 itself primarily hydrolyzes penicillins and early-generation cephalosporins, it is a precursor to many ESBLs that confer resistance to broader-spectrum antibiotics.
- Other names
- SHV-1bla_SHV-1
02
Mechanism of action
Hydrolyzes the beta-lactam ring of beta-lactam antibiotics, rendering them ineffective. Inhibited by beta-lactamase inhibitors.
03
Biological functions
Antibiotic resistanceHydrolyzing beta-lactam antibiotics
04
Disease associations
InfectionAntibiotic resistanceHospital-acquired infections
05
Safety considerations
Spread of antibiotic resistanceTreatment failure due to resistanceEvolution into ESBLs (Extended-Spectrum Beta-Lactamases)Reduced susceptibility to beta-lactamase inhibitors in some mutant forms
06
Interacting drugs
Ampicillin
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