Target intelligence / Profile preview

Beta-N-acetylglucosaminidase (NAG)

Target: NAG
Molecular classification: Enzyme, Glycoside hydrolase

Overview

Beta-N-acetylglucosaminidase (NAG) is a hydrolase enzyme that catalyzes the hydrolysis of terminal N-acetylglucosamine residues from glycans. It plays a crucial role in the degradation and recycling of complex carbohydrates and has implications in lysosomal storage disorders and other diseases.

Other names: GlcNAcaseN-acetyl-β-glucosaminidaseβ-N-acetylglucosaminidase

Mechanism of action

Hydrolyzes terminal β-linked N-acetylglucosamine residues from oligosaccharides, glycoproteins, and glycolipids.

Biological functions

Glycan catabolismLysosomal degradationCell wall recyclingHydrolysis of N-acetyl-glucosides

Disease associations

Lysosomal storage disorders (e.g., Tay-Sachs)Kidney disease (related to diagnostic uses)Cancer (potential role in glycosylation changes)

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