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Target intelligence / Profile preview
Beta Platelet-Derived Growth Factor Receptor (PDGFRβ)
- Target
- PDGFRβ
- Molecular classification
- Receptor, Type III receptor tyrosine kinase, RTK
01
Overview
Beta platelet-derived growth factor receptor (PDGFRβ) is a cell surface receptor tyrosine kinase that plays a critical role in cellular signaling, particularly in processes such as cell proliferation, migration, and survival. PDGFRβ is primarily expressed on pericytes and vascular smooth muscle cells, where it mediates recruitment of these cells to newly formed blood vessels. Mutations or abnormal activity of PDGFRβ are implicated in several diseases, including myeloproliferative neoplasms and leukemia.
- Other names
- PDGFRBPlatelet-derived growth factor receptor beta polypeptide
02
Mechanism of action
Tyrosine kinase inhibition
03
Biological functions
Signal transductionCell proliferationCell migrationCell differentiationCell survivalAngiogenesis
04
Disease associations
Myeloproliferative neoplasms with eosinophiliaBone marrow disordersLeukemia5q-syndrome
05
Safety considerations
Potential progression from chronic bone marrow disorders to aggressive leukemia if left unchecked
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