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Target intelligence / Profile preview
Beta Radiation Emission from Lutetium-177 (Lu-177 Beta Emission)
- Target
- Lu-177 Beta Emission
- Molecular classification
- Radioisotope, Beta-emitter, Gamma-emitter
01
Overview
Lutetium-177 (Lu-177) is a radioactive isotope used in nuclear medicine for targeted radionuclide therapy (TRT). Its therapeutic effect is primarily due to the emission of beta-minus particles, which induce DNA damage and cell death in targeted cells. Lu-177 also emits gamma photons, enabling imaging and dosimetry. It is used in radioligand therapies like Lu-177 DOTATATE and Lu-177 PSMA ligands for treating neuroendocrine tumors and prostate cancer, respectively.
- Other names
- Lutetium-177 Beta Particles177Lu Beta EmissionLu-177 Beta DecayBeta Radiation from Lutetium-177
02
Mechanism of action
Emitted beta-minus particles cause DNA damage within target cells, leading to cell death.
03
Biological functions
DNA damage inductionCell death inductionTargeted radiotherapyImaging (gamma emissions)
04
Disease associations
Cancer TherapyNeuroendocrine tumorsProstate cancerBone metastasesHematological malignancies
05
Safety considerations
Radiation exposureOff-target toxicityMyelosuppressionNephrotoxicity
06
Interacting drugs
Lu-177 DOTATATE
1 more in the full profile.
07
Biomarkers
Somatostatin receptor expression (for Lu-177 DOTATATE)Prostate-specific membrane antigen (PSMA) expression (for Lu-177 PSMA ligands)
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