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Target intelligence / Profile preview
Beta-site amyloid precursor protein cleaving enzyme 2 (BACE2)
- Target
- BACE2
- Molecular classification
- Enzyme, Aspartic protease, A1 family
01
Overview
Beta-site amyloid precursor protein cleaving enzyme 2 (BACE2) is an aspartic protease that cleaves amyloid precursor protein (APP). While it can cleave APP at the β-secretase site, it primarily acts as an α-secretase, preventing the formation of amyloid-beta peptides implicated in Alzheimer's disease. BACE2 is also involved in melanosome morphogenesis and exhibits neuroprotective functions. Its role in diseases such as Down's syndrome and certain cancers is being investigated, and it presents challenges and opportunities for therapeutic development due to its structural similarity with BACE1 and potential for off-target effects.
- Other names
- Beta-secretase 2Transmembrane aspartic proteaseBACE-2
02
Mechanism of action
Protease inhibition
03
Biological functions
Non-amyloidogenic cleavage of APPMelanosome morphogenesisProteolytic processing of amyloid precursor protein (APP)Neuroprotection
04
Disease associations
Down's syndrome dementia riskAlzheimer's DiseaseOsteoarthritisShoulder lesionsCancer
05
Safety considerations
Off-target effects due to structural similarity with BACE1Disruption of BACE2's beneficial roles
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