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Target intelligence / Profile preview
Beta-taxilin (TXLNB)
- Target
- TXLNB
- Molecular classification
- Adapter protein, Centrosomal protein, Intracellular structural protein, Other
01
Overview
Beta-taxilin (TXLNB) is a protein encoded by the human TXLNB gene and is chiefly known as a centrosomal adapter that bridges centrosome dynamics with the ubiquitin-proteasome system, particularly in cardiomyocytes (heart muscle cells)[1][2]. It plays a pivotal role in cardiac proteostasis, promoting proper disposal of damaged or misfolded proteins via the proteasome, and its deficiency leads to accumulation of ubiquitinated proteins and susceptibility to cardiac stress[1][2]. This protein also participates in intracellular vesicle trafficking and is suggested to bind syntaxins[4][5]. Its unique location and function make it a key regulator of cytoskeletal structure and protein quality control but not a direct target for therapeutic drugs at present[1][2][4].
- Other names
- TXLNBBeta-taxilinC6orf198MDP77hMDP77LST001dJ522B19.2
02
Mechanism of action
No pharmacological mechanism of action is described for this target; drugs targeting TXLNB have not been reported
03
Biological functions
Motor nerve regenerationIntracellular vesicle traffickingSyntaxin bindingAdapter for microtubule and UPS interactionsRegulation of cardiac proteostasis
04
Disease associations
Cardiac proteotoxicity/stressCardiac hypertrophyHeart failure (mouse/failing heart studies)Brachial Plexus LesionOrofaciodigital Syndrome VI
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