Betaine--homocysteine S-methyltransferase 2 pseudogene

Betaine--homocysteine S-methyltransferase 2 pseudogene is a nonfunctional DNA segment related to the functional BHMT2 gene. Pseudogenes resemble known genes but do not encode active proteins and typically lack biological function. They do not serve as therapeutic targets, and the biological BHMT2 protein is an active enzyme, but the pseudogene product is not functional in methylation or homocysteine metabolism. Pseudogenes can sometimes be transcribed or affect gene regulation, but are generally not considered druggable targets or relevant to most disease biology[2][4]. Essential context: - This entry corresponds to a *pseudogene*, not a functional protein-coding gene[2]. - Pseudogenes (like this one) typically do **not** produce active proteins or serve as direct therapeutic targets[2][4]. - The *functional* (non-pseudogene) gene is "Betaine--homocysteine S-methyltransferase 2" (BHMT2), which is an enzyme involved in homocysteine metabolism[1][3][5]. The pseudogene does not encode this active enzyme. In summary: "ENSG00000278428" refers to a *pseudogene* of BHMT2. It is not a functional target, does not encode an active receptor or enzyme, and is generally not relevant for drug targeting or clinical biomarker use. Any functional information about methyltransferase activity or enzyme function refers instead to the active BHMT2 gene, not its pseudogene copy[2][4].

Other names

BHMT2 pseudogene