Bicaudal C homolog 1 (BICC1)

Bicaudal C homolog 1 (BICC1) is an evolutionarily conserved, multi-domain RNA-binding protein that regulates gene expression at the post-transcriptional level. It contains several K-homology (KH) domains in its N-terminal region which confer specificity for target mRNA binding, and it can interact with the Ccr4-Not deadenylase complex to modulate mRNA stability and translation. BICC1 is important for embryonic development—especially in left-right patterning in vertebrates—by regulating the translation or decay of specific mRNAs such as **dand5, gdf3**, and **PkD2**. It can repress or, in some cases, activate specific mRNA targets, often interacting with microRNAs and their associated proteins (e.g., AGO2, Dicer) to fine-tune post-transcriptional regulation. Mutations or loss of BICC1 cause cystic kidney and liver diseases in mice and are implicated in human polycystic kidney disease. Rare fusions such as FGFR2-BICC1 occur in certain tumor types and may represent oncogenic drivers[1][2][3][4].

Other names

Protein bicaudal C homolog 1BicCBICCFGFR2-BICC1 fusion kinase proteinbicc1

Not applicable; no known drugs directly target BICC1