Target intelligence / Profile preview

BICD family-like cargo adapter 1 (BICDL1)

Target: BICDL1
Molecular classification: Adapter protein

Overview

BICDL1 acts as an adapter protein linking the dynein motor complex to various cargos, enhancing dynein's processivity. It is involved in vesicle transport and neuron projection development, playing a role in the secretory vesicle machinery in neurons. BICDL1 is located in the centrosome and facilitates the interaction between dynein and dynactin, enabling efficient transport along microtubules.

Other names: BICD-related protein 1BICDR1CCDC64CCDC64ABicaudal D-related protein 1Coiled-coil domain-containing protein 64AFLJ26450H_267D11.1

Mechanism of action

Not applicable as it is not a common therapeutic target.

Biological functions

Vesicle transportNeuron projection developmentGolgi to secretory granule transportInteraction with dynein motor complex

Disease associations

NeuronitisCortical dysplasia with other brain malformations

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