Bifidobacterium animalis subsp. lactis Bl-04 ABC transporter solute-binding protein (Bal6GBP (for the β-galactoside-specific protein); BlG16BP (for the α-glucoside/galactoside-specific protein))

The **Bifidobacterium animalis subsp. lactis Bl-04 ABC transporter solute-binding protein** is a highly specific protein that governs the uptake of particular dietary oligosaccharides, such as β-(1,6)-galactosides and α-(1,6)-linked glucosides/galactosides. These proteins (notably Bal6GBP and BlG16BP) confer a strong preference for specific sugar isomers, enabling the bacterium to utilize certain prebiotics more efficiently than competitors in the human gut[1][2][4]. Structural and functional studies show that this selective uptake underpins the competitive colonization and substrate utilization patterns of *B. animalis* subsp. *lactis* Bl-04, a commonly used probiotic strain[1][2][4]. The binding protein’s precise substrate specificity is reflected in the bacterium’s growth profile and provides an ecological advantage in environments rich in favored oligosaccharides[1][2][4]. The protein is not a human therapeutic target, but plays an important role in the metabolism and competitive fitness of beneficial gut bacteria.

Other names

Bal6GBP (β-galactoside–specific solute-binding protein)BlG16BP (α-(1,6)-glucoside/galactoside-specific solute-binding protein)ABC transporter solute-binding protein from B. animalis subsp. lactis Bl-04