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Target intelligence / Profile preview
Bifunctional Epoxide Hydrolase 2 (sEH)
- Target
- sEH
- Molecular classification
- Enzyme, Epoxide hydrolase, Lipid-phosphate phosphatase
01
Overview
Bifunctional Epoxide Hydrolase 2 (sEH) is an enzyme that possesses both epoxide hydrolase and lipid-phosphate phosphatase activities. It plays a crucial role in regulating the levels of bioactive lipids, particularly epoxides like EETs, which have anti-inflammatory properties. As a drug target, sEH is being explored for various therapeutic areas including cardiovascular disease, pain, and cancer.
- Other names
- Soluble epoxide hydrolaseEpoxide hydratase
02
Mechanism of action
Inhibition of epoxide hydrolysis and/or lipid-phosphate dephosphorylation.
03
Biological functions
Xenobiotic metabolismRegulation of vasoactive lipid levelsHydrolysis of epoxidesHydrolysis of lipid phosphates
04
Disease associations
Familial hypercholesterolemiaCardiovascular diseaseHypertensionPainInflammatory PainUlcersPancreatitisUnspecified Cancer
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