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Target intelligence / Profile preview
Bile Acid Metabolism (BAM)
- Target
- BAM
- Molecular classification
- Metabolic Pathway, Lipid Metabolism, Steroid Metabolism
01
Overview
Bile acid metabolism encompasses the synthesis, transformation, transport, and signaling functions of bile acids, amphipathic molecules derived from cholesterol in the liver. It is essential for intestinal nutrient absorption, biliary secretion of lipids and xenobiotics, and plays a central role in regulating lipid and glucose homeostasis.
- Other names
- Bile Acid SynthesisBile Acid HomeostasisEnterohepatic Circulation of Bile Acids
02
Mechanism of action
Varies depending on the specific drug; includes increasing bile flow, reducing cholesterol absorption, activating FXR receptors, and lowering lipid levels.
03
Biological functions
Fat digestion and absorptionCholesterol homeostasisRegulation of lipid and glucose metabolismEnergy expenditure regulationBiliary secretionSignaling
04
Disease associations
Cholestatic liver diseasesDyslipidemiaNon-alcoholic fatty liver diseaseCardiovascular diseasesDiabetes mellitusBiliary obstruction
05
Safety considerations
Drug-induced liver injuryGastrointestinal side effects (diarrhea, constipation)Malabsorption of fat-soluble vitaminsIncreased risk of gallstone formation
06
Interacting drugs
Ursodeoxycholic acid
5 more in the full profile.
07
Biomarkers
Serum bile acid levelsLiver enzymes (ALT, AST)BilirubinCholesterol levelsTriglyceride levelsFibrosis markers
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