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Target intelligence / Profile preview
Bile Acid Pool (BAP)
- Target
- BAP
- Molecular classification
- Metabolic Pool, Lipid Metabolite
01
Overview
The bile acid pool represents the total circulating mass of bile acids within the enterohepatic circulation. It plays a crucial role in lipid digestion, cholesterol homeostasis, and cell signaling. The pool is composed primarily of cholic acid (CA), chenodeoxycholic acid (CDCA), and deoxycholic acid (DCA), and its size and composition are dynamic, cycling multiple times per day. Alterations in the bile acid pool can have significant clinical consequences, making it a relevant factor in various liver and metabolic disorders.
- Other names
- Total Bile AcidsCirculating Bile AcidsEnterohepatic Bile AcidsBile Salt Pool
02
Mechanism of action
Varies depending on the specific drug and its interaction with bile acid metabolism or signaling. For example, bile acid sequestrants bind bile acids in the intestine, preventing their reabsorption and promoting their excretion. Ursodeoxycholic acid (UDCA) alters the composition of the bile acid pool.
03
Biological functions
Lipid digestion and absorptionCholesterol homeostasisMicelle formationRegulation of gut flora and motilityCell signaling
04
Disease associations
Hepatic diseasesMalabsorption syndromesCholestasisGallstonesMetabolic disorders
05
Safety considerations
Drug interactions with bile acid sequestrantsPotential for fat-soluble vitamin deficienciesExacerbation of certain gastrointestinal conditions
06
Interacting drugs
Bile acid sequestrants (e.g., Cholestyramine, Colestipol, Colesevelam)
3 more in the full profile.
07
Biomarkers
Serum bile acid levelsFecal bile acid levelsBile acid composition
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