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Target intelligence / Profile preview
Bile Acid Synthesis and Cholesterol Solubilization (N/A)
- Target
- N/A
- Molecular classification
- Metabolic pathway, Lipid metabolism, Steroid metabolism
01
Overview
Bile acid synthesis and cholesterol solubilization in bile is a crucial metabolic pathway involving the enzymatic conversion of cholesterol into bile acids in the liver. These bile acids, acting as detergents, solubilize cholesterol and other lipids in bile through micelle formation, facilitating their excretion and aiding in the digestion and absorption of dietary fats. This pathway is essential for maintaining cholesterol homeostasis and preventing various lipid-related disorders.
- Other names
- Bile acid metabolismCholesterol catabolism (bile acids)Biliary cholesterol solubilization
02
Mechanism of action
Bile acid sequestrants bind bile acids in the intestine, preventing their reabsorption and promoting their excretion. Fibrates affect bile acid synthesis through FXR. Ezetimibe inhibits cholesterol absorption.
03
Biological functions
Cholesterol eliminationLipid digestion and absorptionMicelle formationRegulation of cholesterol homeostasis
04
Disease associations
Gallstone formation (cholelithiasis)HypercholesterolemiaCholestasisInherited bile acid synthesis defectsSteatorrhea
05
Safety considerations
Drug interactionsMalabsorption of fat-soluble vitaminsGastrointestinal side effects (constipation, bloating)Potential for increased triglyceride levels (with bile acid sequestrants)Liver toxicity
06
Interacting drugs
Bile acid sequestrants (e.g., cholestyramine, colestipol, colesevelam)
3 more in the full profile.
07
Biomarkers
Serum bile acid levelsCholesterol levels (LDL, HDL)Liver function tests (AST, ALT)Bilirubin levels
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