Bile Acid Transporter Protein

Bile acid transporter proteins are a group of membrane transporters essential for the enterohepatic circulation and homeostasis of bile acids. They mediate the uptake, transcellular movement, and efflux of bile acids across cellular membranes in the liver, intestine, kidney, and other tissues. Key examples include NTCP (SLC10A1), ASBT/IBAT (SLC10A2), and OSTalpha/OSTbeta (SLC51A/SLC51B). These transporters are involved in the reabsorption of bile acids from the intestine back to the liver, as well as the uptake of bile acids from the blood into the liver. Genetic deficiencies and drug interactions targeting these transporters can have significant clinical consequences.

Other names

Bile Salt TransporterBile Acid Uptake TransporterBile Acid Efflux Transporter

Inhibition of bile acid transport