Bile Acids Modulator (BAM)

A bile acids modulator refers to any molecule or agent that influences the synthesis, signaling, transport, or metabolism of bile acids. Bile acids themselves are amphipathic molecules derived from cholesterol in the liver and play essential roles in digestion, metabolic regulation, immune modulation, and gut microbiota composition. Key receptors targeted are FXR and TGR5. They have been investigated for liver and metabolic disorders.

Other names

Bile Acid Receptor AgonistBile Acid Receptor AntagonistFXR AgonistFXR AntagonistTGR5 AgonistTGR5 AntagonistIBAT InhibitorBile Acid Synthesis ModulatorBile Acid Transport ModulatorBile Acid Metabolism Modulator

Agonism/antagonism at nuclear receptors (e.g., FXR); Influencing membrane-bound GPCRs (e.g., TGR5); Altering enterohepatic circulation via transporter inhibition (e.g., IBAT inhibitors)