Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Bile Salt Export Pump (BSEP)
- Target
- BSEP
- Molecular classification
- Transporter, ATP-binding cassette transporter
01
Overview
Bile Salt Export Pump (BSEP), encoded by the ABCB11 gene, is a critical ATP-dependent efflux transporter located on the canalicular membrane of hepatocytes. It facilitates the export of conjugated bile acids from hepatocytes into bile, driving bile formation and enterohepatic circulation. Impairment or inhibition of BSEP function leads to intrahepatic cholestasis and drug-induced liver injury. BSEP expression is regulated by several nuclear receptors, including FXR, AMPK, LRH-1 and Nrf2. Several marketed drugs have been implicated in BSEP inhibition and subsequent liver injury.
- Other names
- ABCB11ATP-binding cassette sub-family B member 11
02
Mechanism of action
Inhibition of bile salt export from hepatocytes into the bile canaliculi
03
Biological functions
Bile acid transportEnterohepatic circulation
04
Disease associations
Intrahepatic cholestasisDrug-induced liver injuryProgressive familial intrahepatic cholestasis type II
05
Safety considerations
HepatotoxicityDrug-induced liver injuryInterspecies differences in drug response
06
Interacting drugs
Pravastatin
3 more in the full profile.
Beyond the preview
Go deeper on Bile Salt Export Pump (BSEP).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Bile Salt Export Pump (BSEP).