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Biliverdin Reductase B (BLVRB)
- Target
- BLVRB
- Molecular classification
- Enzyme, Oxidoreductase
01
Overview
Biliverdin Reductase B (BLVRB) is an NADPH-dependent cytosolic enzyme crucial in heme metabolism, catalyzing the reduction of biliverdin to bilirubin. It acts as a flavin reductase, reducing flavins, biliverdins (excluding biliverdin IXα), pyrroloquinoline quinone (PQQ), and ferric ion. BLVRB also functions as a protein nitrosyltransferase, catalyzing the nitrosylation of cysteine residues on target proteins. It plays a vital role in cellular redox homeostasis and has clinical relevance as a biomarker for vascular injury and stroke risk. It is more active during fetal development compared to postnatal life.
- Other names
- Flavin reductase (NADPH)
02
Mechanism of action
Catalyzes the NADPH-dependent reduction of biliverdin to bilirubin. Functions as a protein nitrosyltransferase.
03
Biological functions
Heme metabolismReduction of biliverdin to bilirubinProtein nitrosyltransferaseRedox homeostasisAntioxidant activity
04
Disease associations
Cardiovascular diseaseIschemic strokeMetabolic diseaseOxidative stress-related diseases
05
Biomarkers
Plasma biomarker for intraplaque hemorrhagePredictor of ischemic stroke risk
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