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Target intelligence / Profile preview
Binary toxin CDT (CDT)
- Target
- CDT
- Molecular classification
- Toxin, ADP-ribosyltransferase, Binary Toxin
01
Overview
Binary toxin CDT is a two-component exotoxin produced by some *C. difficile* strains that enhances virulence through disruption of host cell actin dynamics and promotion of bacterial adherence via unique cellular protrusions. Its presence serves as both a marker for more severe disease risk and as an emerging target for novel therapeutics aimed at mitigating serious outcomes from CDI caused by hypervirulent lineages.
- Other names
- Clostridioides difficile transferaseCDTa/CDTb
02
Mechanism of action
CDTa ADP-ribosylates G-actin, preventing actin polymerization and causing cytoskeletal collapse.
03
Biological functions
ADP-ribosylation of actinDisruption of actin cytoskeletonInduction of microtubule-based protrusionsEnhanced bacterial adherenceImmune response modulation
04
Disease associations
Clostridioides difficile infection (CDI)Increased disease severity in CDIIncreased mortality in CDI
05
Safety considerations
Potential for off-target effects if targeting the actin cytoskeletonDevelopment of resistance to therapies targeting CDT
06
Biomarkers
Presence of CDT genes in C. difficile isolates
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