Biofilm matrix on wound surface

The **biofilm matrix on wound surface** refers to the extracellular matrix, primarily composed of polysaccharides, extracellular DNA, proteins, and lipids, secreted by microbial communities adhering to wound beds[1][2][3][5][7]. This matrix physically encases and protects bacteria and other microorganisms, forming a structured, three-dimensional network that impairs host immune defenses, reduces antibiotic penetration, and facilitates chronic infection[1][2][4][5][6][7]. The biofilm matrix is a major barrier to healing in chronic wounds, requiring targeted disruption (e.g., by specific cleansers or dressings) for effective treatment. The composition and structure of the matrix can vary, but its principal functions are to support microbial survival, promote aggregation, and defend against hostile environmental factors, including medical therapies and host immunity[1][3][4][5][7].

Other names

biofilm extracellular matrixextracellular polymeric substance of biofilmwound biofilm matrixbiofilm EPS

Chemical disruption of matrix polysaccharides; Enhanced accessibility of antimicrobials via matrix breakdown; Mechanical removal after matrix destabilization