Biomechanical and neuromuscular function (as modulated by physical rehabilitation techniques)

This term refers to the *systems and processes within the human body that are targeted by physical rehabilitation techniques*, such as neuromuscular training, neuromuscular re-education, and biomechanical retraining. These interventions do not act on a specific molecular target, but rather aim to improve motor control, functional stability, strength, balance, proprioception, and coordination through repeated movement, exercise, and manual therapy. The goal is to normalize movement patterns, decrease risk of injury, and restore or optimize functional performance following injury, disease, or dysfunction[1][2][3][4][5][6][7]. Rehabilitation approaches frequently assess and attempt to remediate deficits in the biomechanical and neuromuscular domains, recognizing that long-term improvements arise from neuroplastic changes in the integration of central and peripheral nervous systems with musculoskeletal structures[2][3][4][5][6]. In summary, \"biomechanical/neuromuscular targets via physical rehabilitation techniques\" are *not molecular or receptor targets*. They refer to the *functional characteristics of movement and control* that clinicians address by applying physical exercises, motor learning, and manual techniques. This terminology is incorrect for databases intending to catalog druggable molecular entities. The term should be revised to refer to specific molecules, receptors, or pathways if molecular targeting is intended.

Other names

Biomechanical functionNeuromuscular systemNeuromuscular controlFunctional movement targets