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Target intelligence / Profile preview
Birch Group Pollen Allergens (Bet v)
- Target
- Bet v
- Molecular classification
- PR-10 protein (Bet v 1), Profilin (Bet v 2), Polcalcin (Bet v 3/4), Isoflavone reductase (Bet v 6), Cyclophilin (Bet v 7), Glutathione-S-transferase (Bet v 8), Allergen
01
Overview
Birch group pollen allergens are a set of proteins found in the pollen of birch trees that are responsible for triggering allergic reactions in sensitized individuals. The primary allergenic protein is Bet v 1, a PR-10 protein. Other notable allergens include Bet v 2 (profilin) and Bet v 3/4 (polcalcins). These allergens exhibit significant cross-reactivity with other tree pollens and plant-derived foods, leading to conditions like oral allergy syndrome.
- Other names
- Birch pollen allergensBet v 1Bet v 2Bet v 3Bet v 4Bet v 6Bet v 7Bet v 8
02
Mechanism of action
Antihistamines block histamine receptors; corticosteroids reduce inflammation; allergen immunotherapy induces tolerance.
03
Biological functions
Allergen-induced IgE productionMast cell degranulationImmune responseCross-reactivity with plant proteins
04
Disease associations
Allergic rhinitisAllergic conjunctivitisAsthmaPollen-Food Allergy Syndrome (PFAS)Oral Allergy Syndrome (OAS)
05
Safety considerations
Anaphylaxis (rare with pollen exposure, more relevant with immunotherapy)Cross-reactivity with food allergensSide effects of antihistamines and corticosteroids
06
Interacting drugs
Antihistamines
3 more in the full profile.
07
Biomarkers
IgE antibodies to Bet v 1IgE antibodies to Bet v 2Skin prick test reactivity to birch pollenBasophil activation test
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