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Birch Homologous Group Pollen Allergen
- Molecular classification
- Allergen, PR-10 pathogenesis-related proteins
01
Overview
The "birch homologous group pollen allergen" encompasses highly similar proteins found in several Fagales trees' pollens. The dominant molecule is *Betula verrucosa*'s major allergen *Bet v 1*, which defines both diagnosis and treatment strategies for related tree pollinosis due its strong cross-reactivity with corresponding allergens from alder (*Aln g*), hazel (*Cor a*), oak (*Que a*), hornbeam (*Car b*), chestnut (*Cas s*), and beech (*Fag s*) trees. This molecular similarity underpins both clinical symptoms across different tree pollens and successful broad-spectrum allergy immunotherapy using primarily birch-derived products.
- Other names
- Bet v 1 homologous groupFagales tree pollen allergensPR-10 protein allergens (Fagales)Alder-Hazel-Oak allergen group
02
Mechanism of action
Allergen immunotherapy: Induction of allergen-specific IgG antibodies, T-cell tolerance; Antihistamines: H1 receptor antagonists; Corticosteroids: Suppression of inflammation
03
Biological functions
IgE bindingT-cell activation (in sensitized individuals)Induction of allergic response
04
Disease associations
Allergic rhinitisAllergic asthmaOral Allergy Syndrome
05
Safety considerations
Anaphylaxis (with allergen immunotherapy)Side effects of antihistamines (drowsiness, dry mouth)Side effects of corticosteroids (long-term use)Cross-reactivity can lead to unexpected allergic reactions
06
Interacting drugs
Allergen immunotherapy (birch pollen extract)
2 more in the full profile.
07
Biomarkers
IgE levels specific to Bet v 1 and related allergensSkin prick test reactivity to birch, alder, hazel, oak, etc.
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