Target intelligence / Profile preview

Birch pollen allergen Bet v 1 (Bet v 1)

Target: Bet v 1
Molecular classification: Pathogenesis-related protein class 10, PR-10 protein

Overview

Bet v 1 is the major allergen found in birch (Betula verrucosa) pollen and is recognized as the primary cause of birch pollen allergy, which can lead to allergic rhinitis, asthma, and other IgE-mediated hypersensitivity reactions. It is a member of the pathogenesis-related protein family PR-10 and serves as a marker for primary sensitization to birch pollen. While its precise biological function remains under investigation, Bet v 1 and related PR-10 proteins are believed to play roles in plant defense responses against pathogens, transport or storage of apolar ligands such as plant hormones or secondary metabolites, and growth and development processes within plants.

Other names: Bet v1Bet v 1a

Mechanism of action

Immunotherapy targeting Bet v 1 aims to desensitize individuals to the allergen, reducing IgE-mediated responses.

Biological functions

Plant defense responses against pathogensTransport or storage of apolar ligands (plant hormones or secondary metabolites)Ligand binding

Disease associations

Allergic rhinitisAsthmaOral allergy syndromeFood allergy

Safety considerations

Potential for anaphylaxis during immunotherapyCross-reactivity with other allergens (alder, hazel, apple, hazelnut)

Biomarkers

IgE antibodies specific for Bet v 1

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