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Target intelligence / Profile preview
Birch pollen major allergen Bet v 1 (Bet v 1)
- Target
- Bet v 1
- Molecular classification
- Pathogenesis-related protein class 10 (PR-10), Allergen
01
Overview
Birch pollen major allergen Bet v 1 is the major allergen found in birch pollen (*Betula verrucosa*), responsible for triggering allergic reactions in a significant proportion of individuals with birch pollen allergy. It is the prototypical member of the pathogenesis-related protein class 10 (PR-10) family. Its structure includes a hydrophobic cavity capable of binding various ligands, and surface-exposed regions responsible for cross-reactivity with homologous allergens.
- Other names
- Bet v1Bet v 1a
02
Biological functions
Ligand bindingLigand transportDefense mechanism against pathogens (in plants)
03
Disease associations
AllergyPollen allergy
04
Safety considerations
Cross-reactivity with other pollen allergens (alder, hazel, hornbeam)
05
Biomarkers
IgE reactivity to Bet v 1 (diagnostic marker for birch pollen allergy)
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