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Target intelligence / Profile preview
Birch pollen protein (Bet v 1)
- Target
- Bet v 1
- Molecular classification
- Pathogenesis-related class 10 (PR-10) protein, Allergen
01
Overview
Bet v 1 is the major allergen in birch pollen, belonging to the PR-10 protein family. It is a small protein with a hydrophobic cavity that binds ligands like flavonoids and iron. It plays a role in plant defense but is clinically relevant as the primary cause of birch pollen allergy, leading to allergic rhinitis and asthma. Sensitization is geographically variable, and cross-reactivity with other Fagales trees and certain foods is common. The allergenic potential is influenced by its ligand-binding state.
- Other names
- Bet v 1Major birch pollen allergen
02
Mechanism of action
Immunotherapy (allergen-specific)
03
Biological functions
Plant defenseAllergen presentationLigand binding
04
Disease associations
Allergic rhinitisAsthmaOral allergy syndrome
05
Safety considerations
Potential for severe allergic reactions (anaphylaxis) during immunotherapyCross-reactivity with other pollens and foods
06
Biomarkers
IgE antibodies specific for Bet v 1
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