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Target intelligence / Profile preview
BK polyomavirus early region precursor mRNA
- Molecular classification
- Other (Viral precursor mRNA intermediate)
01
Overview
BK polyomavirus early region precursor mRNA is a primary transcript produced from the early region of the BK polyomavirus genome. This transcript undergoes alternative splicing to produce separate mRNAs that encode the large T antigen, small t antigen, and truncated T antigen, which are viral regulatory proteins essential for viral DNA replication and manipulation of the host cell environment. The transcript, as a precursor mRNA, is further regulated by viral microRNAs (miRNAs) that cleave or repress early viral mRNAs to modulate replication and immune evasion.
- Other names
- BK polyomavirus early transcriptBKPyV early region primary transcriptBK polyomavirus early pre-mRNA
02
Biological functions
Encodes regulatory early proteins (large T antigen, small t antigen) through alternative splicingRegulates viral genome replication and host cell interactionsSubstrate for viral and host-encoded microRNAs regulating viral gene expression
03
Disease associations
Infection (BK polyomavirus-associated nephropathy, especially in immunocompromised patients)
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