Bladder cancer associated transcript 1 (BLACAT1) (BLACAT1)

Bladder cancer associated transcript 1 (BLACAT1) is a long non-coding RNA (lncRNA) of more than 200 nucleotides, lacking protein-coding capacity, and primarily nuclear in localization[1][2]. It regulates gene expression at the transcriptional and epigenetic levels, often through interaction with the polycomb repressive complex 2 (PRC2), leading to the trimethylation of histone H3 lysine 27 (H3K27me3) and silencing of tumor suppressor genes such as p15[1][2]. BLACAT1 is aberrantly overexpressed in multiple cancers and consistently associated with tumor progression, metastasis, and poor prognosis[1][2]. Its depletion results in decreased proliferation, increased apoptosis, and reduced metastatic ability in cancer models. Currently, BLACAT1 is considered a promising prognostic biomarker and a potential, though still preclinical, therapeutic target in oncology[1][2].

Other names

linc-UBC1LINC00912onco-lncRNA-30long intergenic noncoding RNA up-regulated in bladder cancerlong intergenic non-protein coding RNA 912bladder cancer associated transcript 1 (non-protein coding)

Not applicable (no direct-acting drugs known). Antisense RNA/lncRNA-targeting approaches could downregulate BLACAT1, resulting in reduced proliferation and increased apoptosis in cancer cells[1][2].