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Bladder Mucosal Protection (None)

Target: None
Molecular classification: Other

Overview

Bladder mucosal protection refers to the collective mechanisms and molecular components that safeguard the urinary bladder’s inner lining (urothelium) from pathogens, toxins, and irritants present in urine. This protective system is crucial for preventing infections (such as urinary tract infections), inflammation, and chemical injury. It encompasses the mucus/GAG layer, uroplakins, tight junctions, and specialized lipids. Dysfunction leads to UTIs and inflammation.

Mechanism of action

Restoration of barrier function

Biological functions

Barrier against pathogensBarrier against toxinsTissue integrity maintenancePrevention of microbial adherence and invasionProtection against irritants/carcinogens in urine

Disease associations

Urinary tract infections (UTIs)Interstitial cystitisInflammation

Interacting drugs

Intravesical liposomes

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