Molecular Classification
Smooth Muscle, Muscle Tissue
Other Names
Detrusor Muscle
Disease Roles
Overactive bladder syndromeUrinary retentionNeurogenic bladder

Bladder Smooth Muscle Overview

Bladder smooth muscle, also known as the detrusor muscle, is the primary muscular component of the urinary bladder wall. It consists of bundles of smooth muscle fibers oriented in multiple directions, allowing for significant distension and contraction during urine storage and voiding. Excitability and contractility depend on a variety of ion channels expressed on UBSM cells, including voltage-gated calcium channels, potassium channels, and chloride channels.

Mechanism of Action

Modulation of smooth muscle contraction via various receptors and ion channels.

Biological Functions

Urine storage
Micturition
Bladder contraction
Bladder relaxation

Disease Associations

Overactive bladder syndrome
Urinary retention
Neurogenic bladder

Safety Considerations

  • Altered bladder function can lead to urinary retention or incontinence.
  • Adverse effects related to drugs affecting bladder smooth muscle (e.g., anticholinergics)

Interacting Drugs

Carbachol