BLOC-2 complex member HPS5 (HPS5)

BLOC-2 complex member HPS5 (abbreviated HPS5) is a subunit of the Biogenesis of Lysosome-related Organelles Complex-2 (BLOC-2) and plays a crucial role in the formation and function of lysosomes and highly specialized organelles, notably melanosomes and platelet dense granules. The complex is composed of HPS3, HPS5, and HPS6 proteins, and participates in vesicular trafficking and organelle biogenesis. Mutations in the HPS5 gene are causative for Hermansky-Pudlak syndrome type 5, an autosomal recessive disorder characterized by albinism and bleeding diathesis due to impaired organelle formation[1][5][3][8]. There is no established evidence that HPS5 is a druggable target, and there are no drugs known to directly interact with it.

Other names

Alpha-integrin-binding protein 63Hermansky-Pudlak syndrome 5 proteinAIBP63KIAA1017Ru2BLOC2S2Ruby-eye protein 2 homolog

Not applicable; no drugs target HPS5 directly.