BLOC1S5-TXNDC5 readthrough (BLOC1S5-TXNDC5)

BLOC1S5-TXNDC5 readthrough is a non-protein coding RNA generated by read-through transcription between the adjacent *MUTED* (BLOC1S5) and *TXNDC5* genes on chromosome 6[1][7]. The transcript is a candidate for nonsense-mediated mRNA decay and does not produce a protein. While standard gene annotations link it to isomerase activity and organelle biogenesis based on its parental genes, the readthrough itself has no recognized protein function. Disease associations are relevant mainly via functional roles of *BLOC1S5* and *TXNDC5*, not the readthrough transcript. In cancer research, some data identify this RNA as part of a prognostic ferroptosis gene set in breast cancer, suggesting potential use as a disease biomarker, though it is not itself a drug target or functional receptor[5][7]. In summary: BLOC1S5-TXNDC5 readthrough is not a protein-coding gene or therapeutic target, but rather a non-coding RNA with limited known biological and clinical relevance. Most research ties its disease links to parental genes, and its direct functional or pharmacological roles are not established[1][7][5].

Other names

MUTED-TXNDC5BLOC1S5-TXNDC5 readthrough (non-protein coding)MUTED-TXNDC5 readthrough (non-protein coding)BLOC1S5-TXNDC5

Not applicable (no protein product, not a therapeutic target)