Blood circulation promotion via multi-herbal synergy in TCM theory

"Blood circulation promotion via multi-herbal synergy in TCM theory" is a traditional Chinese medicine therapeutic concept, not a single molecule, receptor, or gene. It refers to the use of multiple herbs—each with different mechanisms—to synergistically improve blood circulation, reduce blood stasis (obstruction/sluggishness of blood), and treat related disorders such as cardiovascular diseases, diabetes complications, and vascular dysfunction. While mechanism studies have identified endpoints such as antiplatelet activity, vasorelaxation, endothelial protection, and Na⁺/K⁺-ATPase inhibition, this therapeutic principle is not reducible to any one molecular target[1][3][4][5]. Rather, it encompasses a polypharmacological, system-level intervention characteristic of TCM formulations. This entry does not map to a canonical drug target and should be flagged as improper or non-specific for structured target data.

Other names

Blood circulation activation (TCM)Blood stasis removal (TCM)Huoxue Huayu (活血化瘀)TCM blood-moving therapy

Antiplatelet aggregation (e.g., inhibition of TXA₂/PGI₂ imbalance); Vasodilation; Protection of vascular endothelium and basement membrane; Inhibition of Na⁺/K⁺-ATPase (through steroid-like compounds); Modulation of calcium signaling in myocardium; Inhibition of advanced glycation end-product formation; Antioxidant and lipid-lowering effects