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The phrase describes a therapeutic strategy to promote blood circulation using interventions that act through multiple pathways, including the suppression of inflammation and improvement of microcirculatory blood flow. It is not a single molecular target, but rather refers to a physiological concept involving many proteins and signaling pathways, such as vascular endothelial growth factor, nitric oxide synthase, and anti-inflammatory mediators (e.g., cytokines), all of which contribute to vascular health, tissue perfusion, and protection from inflammatory and ischemic damage.
Vasodilation, Endothelial function enhancement, Reduction of vascular inflammation, Improvement of microvascular perfusion
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