Target intelligence / Profile preview

Blood flow at aneurysm neck

Molecular classification
Other
01

Overview

Blood flow at aneurysm neck" refers to the velocity, pattern, and hemodynamic characteristics of blood as it enters an intracranial aneurysm from the parent artery across the anatomical neck (ostium) of the aneurysm. This parameter is crucial in determining **wall shear stress (WSS), pressure distribution, and turbulence** at the neck and within the aneurysm dome. Zones of high velocity or concentrated inflow jets at the aneurysm neck are associated with **elevated WSS and localized wall stress**, which may promote aneurysm growth, rupture, or hinder thrombosis after treatment. Conversely, stasis or low-flow states are linked to **thrombus formation** and wall degeneration. Modern endovascular therapies (e.g., flow diverters, coiling) are designed to modulate this flow to stabilize or exclude the aneurysm from circulation. This term is a **descriptive hemodynamic or imaging biomarker**, not a molecule, protein, or classical 'target' in the therapeutic sense. It is not suitable as a canonical "target" entry.

Other names
Blood flow at neck of aneurysmHemodynamics at aneurysm neckInflow at aneurysm neckBlood velocity at aneurysm ostium
02

Biological functions

Regulation of vessel wall shear stressInfluence on aneurysm wall stabilityDetermination of risk for aneurysm ruptureImpacts endothelial cell function and local inflammatory response
03

Disease associations

Cardiovascular diseaseCerebrovascular/aneurysmal diseaseStroke risk
04

Safety considerations

High flow or abnormal shear at the neck may promote aneurysm growth, instability, or ruptureIncomplete flow reduction after intervention may risk recurrence
05

Biomarkers

Wall shear stressOscillatory shear indexBlood flow velocity at aneurysm neck (as measured by imaging/CFD modeling)

Beyond the preview

Go deeper on Blood flow at aneurysm neck.

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Drug pipeline

Full profile access

Explore the programs pursuing this target and their development progress.

  • Drug candidates
  • Developers
  • Development stage

Clinical trials

Full profile access

Follow the clinical studies evaluating therapies directed at this target.

  • Trial design
  • Status
  • Readouts

Competitive landscape

Full profile access

Compare approaches across drug candidates, modalities, and indications.

  • Programs
  • Modalities
  • Indications

Literature & evidence

Full profile access

Investigate the research and source evidence behind target biology and development.

  • Publications
  • Sources
  • Analysis

Patents

Full profile access

Explore patent activity around therapies and technologies addressing this target.

  • Patents
  • Assignees
  • Technologies

Research & analysis

Full profile access

Connect target biology, drug development, and emerging evidence in your research.

  • Biology
  • Development news
  • Analysis

Bring the full picture into focus.

See how Gosset can support your research on Blood flow at aneurysm neck.

Explore the full profile

Gosset Free

Get started with Gosset.

Enter your work email and we’ll be in touch with next steps.

Work email preferred.

Book a call