Target intelligence / Profile preview

Blood glucose level

Molecular classification
Other
01

Overview

Blood glucose level refers to the concentration of glucose present in the blood. It is not a molecule or receptor but rather a physiological measurement that reflects the amount of circulating sugar available for cellular energy use. Blood glucose levels are tightly regulated by hormones such as insulin (which lowers blood sugar) and glucagon (which raises it), both produced by the pancreas. Abnormalities in this regulation can lead to diseases such as diabetes mellitus, characterized by chronic hyperglycemia, or acute conditions like hypoglycemia. Drugs that interact with this system include insulin preparations, sulfonylureas that increase endogenous insulin secretion, and glucagon used to treat severe low blood sugar episodes. Monitoring blood glucose is essential in managing diabetes and preventing complications related to abnormal levels[1][3][5][7][8]. Note: "Blood glucose level" is not itself a molecular target but an important clinical parameter reflecting metabolic status; therefore, it does not have canonical molecular nomenclature or classification as a therapeutic target.

Other names
Blood sugarPlasma glucoseSerum glucose
02

Mechanism of action

Insulin lowers blood glucose by promoting cellular uptake and storage as glycogen[1][3][5][8] - Sulfonylureas stimulate insulin secretion from pancreatic beta cells[8] - Glucagon raises blood glucose by stimulating hepatic glycogenolysis and gluconeogenesis[1][3][5]

03

Biological functions

Energy source for cellsMetabolic intermediate
04

Disease associations

DiabetesHypoglycemiaHyperglycemia
05

Safety considerations

Risk of hypoglycemia with insulin or sulfonylurea therapy[8]
06

Interacting drugs

Insulin (and analogs)

2 more in the full profile.

07

Biomarkers

Blood glucose level itself is a biomarker for diabetes diagnosis, monitoring, and hypoglycemia/hyperglycemia management[8]

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