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Target intelligence / Profile preview
Blood group Rh(D) polypeptide (RhD)
- Target
- RhD
- Molecular classification
- Transmembrane protein, Antigen, Possible transporter
01
Overview
The Blood group Rh(D) polypeptide is a critical erythrocyte membrane component responsible for defining one’s “Rh-positive” status via expression of the highly immunogenic D antigen. Its proper function depends on interaction with other related membrane proteins such as RhAG. While best known for its role in transfusion compatibility and maternal-fetal medicine due to antibody formation risks when absent/mismatched between donor-recipient pairs, it also contributes structurally/functionally to red cell integrity—possibly acting as an ammonia transporter within a larger multiprotein complex.
- Other names
- CD240DDIIIcRHRH30RHCEDRHDVA(TT)RHDelRHPIIRHXIIIRh4Blood group antigen D polypeptide
02
Biological functions
Antigen presentationRed blood cell membrane integrityPossible ammonium/CO₂ transport
03
Disease associations
Hemolytic disease of the fetus/newbornRhD alloimmunizationRh null disease (mild hemolytic anemia)
04
Safety considerations
RhD alloimmunization in RhD-negative individualsHemolytic transfusion reactionsHemolytic disease of the fetus/newborn
05
Biomarkers
RhD antigen presence/absence (for blood typing)Anti-D antibodies
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