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Plasma (blood plasma) (None)
- Target
- None
- Molecular classification
- Other (extracellular matrix/fluid compartment; not a protein, enzyme, receptor, or standard molecular target)
01
Overview
The **aqueous plasma matrix** refers to the liquid portion of blood that acts as the primary extracellular matrix for blood cells. It is a straw-colored, viscous fluid that makes up approximately 55% of total blood volume. Plasma is composed of about 90-92% water, with the rest comprising proteins (mainly albumin, globulins, and fibrinogen), electrolytes, nutrients, hormones, waste products, and dissolved gases. Plasma supports the transport of substances throughout the body, maintains osmotic balance and pH, and provides a medium for immune responses and coagulation. However, it is not a drug target, receptor, or single molecular entity.
- Other names
- blood plasmaplasma matrixfluid matrix of blood
02
Mechanism of action
Not applicable; plasma is not an active target for drug action
03
Biological functions
Transport of nutrients, hormones, and metabolic wasteMaintenance of blood pressure and volumeOsmotic balanceBuffering of pHImmune defense (through plasma proteins/antibodies)Clotting (via fibrinogen and clotting factors)
04
Disease associations
Other (Imbalance or abnormality can be implicated in a very broad range of disease states through transport dysfunction, clotting disorders, immune deficiencies, etc.; plasma per se is not a "target" of disease, but its composition is clinically relevant)
05
Safety considerations
Plasma transfusion: risk of allergic reaction, infection, volume overloadAltered plasma composition in disease (e.g., low albumin in liver disease, abnormal clotting factors in coagulopathies)
06
Interacting drugs
None specific (plasma provides the medium for circulating drugs; plasma-derived products—such as plasma expanders—are used therapeutically, and plasma proteins, like albumin, may be given, but "plasma" itself is not directly targeted by specific drugs)
07
Biomarkers
Multiple (individual plasma proteins and metabolites—albumin, globulins, fibrinogen, glucose, electrolytes—are clinically measured as biomarkers, but "aqueous plasma matrix" as a whole is not)
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