Blood pressure regulation pathways

Blood pressure regulation pathways refers to the complex network of molecular, cellular, and tissue-level signaling mechanisms that maintain and adjust arterial blood pressure. These pathways integrate signals from the kidney, vasculature, central nervous system, and endocrine organs and involve molecules such as hormones (renin, angiotensin II, aldosterone), receptors (angiotensin II type 1 receptor, mineralocorticoid receptor, adrenergic receptors), endothelial factors (nitric oxide, endothelin), and inflammatory/immune mediators[2][3]. Key pathways include the renin–angiotensin–aldosterone system, sympathetic nervous system, nitric oxide-cGMP signaling, calcium signaling, and immune/inflammatory processes[2][3][5]. While each of these pathways involves druggable molecular targets, "Blood pressure regulation pathways" itself is not a discrete target but a collection of targets, mechanisms, and regulatory feedback loops that can be therapeutically modulated to prevent or treat hypertension and its complications[2][5]. This entry is considered too broad and not suitable for use as a canonical therapeutic target. For structured information, individual components (such as "Angiotensin II type 1 receptor" or "Renin") should be used as specific targets.

Other names

Blood pressure pathwaysHypertension regulatory pathwaysBlood pressure control mechanisms