Blood rheology modulation

Blood rheology modulation refers to the therapeutic or experimental alteration of blood’s flow properties, namely viscosity and associated rheological factors (cellular and plasma), to improve tissue perfusion and reduce disease risk or severity[1][3][9]. Blood viscosity is determined predominantly by the concentration and deformability of red blood cells and large plasma proteins, with increased viscosity linked to cardiovascular events and vascular injury[1]. Key modulators include drugs or interventions that improve RBC deformability, reduce aggregation, or lower plasma viscosity. Though modulation of blood rheology is a valid therapeutic strategy in several diseases, "blood rheology modulation" itself is not a molecular target but a therapeutic objective or intervention principle[1][3][9].

Other names

Blood rheology alterationHemorheology modulationBlood flow properties modulationHemorheological intervention

Decreasing plasma viscosity; improving red blood cell deformability; reducing red blood cell aggregation; modifying plasma protein concentration (e.g., fibrinogen)