Blood stasis-related metabolic pathways

Blood stasis-related metabolic pathways refer to the network of biochemical, hematological, and vascular alterations that underlie or result from the TCM syndrome known as blood stasis. This syndrome is characterized by impaired blood flow, increased viscosity, microvascular dysfunction, hypercoagulability, ischemia, and tissue hypoxia. Mechanisms involve abnormal activation of coagulation, upregulation of hypoxia-inducible and angiogenic factors (e.g., HIF1-α, VEGF), and changes in cellular metabolism, often overlapping with modern concepts of hypercoagulable states, microthrombi, and local tissue injury. While "blood stasis" is widely studied for its role in cancer progression, cardiovascular disease, stroke, and inflammation, it is not a defined molecular entity but rather a composite pathological state encompassing various metabolic and signaling abnormalities.

Other names

Blood stasis syndromeBlood stagnationBlood stasis metabolic pathwaysBSS-related metabolic pathways

Anticoagulation, antiplatelet action, vascular protection, and herbal modulation of inflammation, hemodynamics, and tissue metabolism.