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Target intelligence / Profile preview
Blood Vessel Endothelium
- Molecular classification
- Cell Type, Tissue Component
01
Overview
The blood vessel endothelium is a single layer of squamous endothelial cells that lines the interior surface of all blood vessels. It plays essential roles in vascular biology and homeostasis, including barrier function, vascular tone regulation, hemostasis, inflammation, and angiogenesis. Endothelial dysfunction is implicated in many diseases, including atherosclerosis, hypertension, and thrombosis.
- Other names
- Vascular EndotheliumEndothelial cellsEndothelium
02
Biological functions
Barrier functionVascular tone regulationHemostasisInflammationImmunityAngiogenesisRegulation of blood flowRegulation of vascular permeability
03
Disease associations
AtherosclerosisHypertensionThrombosisChronic inflammationCardiovascular diseaseEdemaTumor angiogenesis
04
Safety considerations
Endothelial dysfunction can lead to various cardiovascular and metabolic diseases.Targeting endothelial cells may have off-target effects on other tissues.
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