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Blood Volume Expansion via Colloid Effect
- Molecular classification
- Physiological Process, Pharmacological Mechanism
01
Overview
Blood volume expansion via the colloid effect refers to the use of intravenous solutions containing large, insoluble molecules (colloids) to increase and maintain intravascular blood volume. This is achieved by increasing the osmotic pressure within blood vessels, drawing water from the interstitial and intracellular spaces into the intravascular compartment, expanding plasma volume. It is primarily used for fluid resuscitation in hypovolemic states.
- Other names
- Colloid Osmotic EffectPlasma Volume ExpansionIntravascular Volume AugmentationFluid Resuscitation (Colloid)
02
Mechanism of action
Osmotically active macromolecules draw water into vasculature
03
Biological functions
Fluid homeostasisBlood pressure regulationTissue perfusionOsmotic regulation
04
Disease associations
HypovolemiaShockHemorrhageHypoproteinemiaSepsisTrauma
05
Safety considerations
Fluid overloadPulmonary edemaCoagulopathiesAllergic reactions/anaphylaxisRenal dysfunction/acute renal failureCapillary leak syndromeIncreased intracranial pressure
06
Interacting drugs
Albumin
3 more in the full profile.
07
Biomarkers
Blood pressureHeart rateUrine outputCentral venous pressure (CVP)Pulmonary artery wedge pressure (PAWP)HemoglobinHematocritSerum albuminLactate
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